Monday, October 27, 2025

Global Vascular Endothelial Growth Factor B Market Research Report 2025

What is Global Vascular Endothelial Growth Factor B Market?

The Global Vascular Endothelial Growth Factor B (VEGF-B) Market is a specialized segment within the broader medical and pharmaceutical industry, focusing on the development and commercialization of therapies targeting VEGF-B. VEGF-B is a protein that plays a crucial role in the formation of blood vessels, a process known as angiogenesis. This market is driven by the increasing understanding of VEGF-B's role in various diseases, including cancer, cardiovascular diseases, and eye disorders. As research progresses, the potential therapeutic applications of VEGF-B inhibitors or modulators are expanding, leading to increased interest from pharmaceutical companies and researchers. The market encompasses a range of products, including biologics, small molecules, and biosimilars, each with unique mechanisms of action and therapeutic potential. The growing prevalence of chronic diseases, coupled with advancements in biotechnology, is expected to fuel the growth of the VEGF-B market. Additionally, collaborations between academic institutions and pharmaceutical companies are fostering innovation and accelerating the development of new therapies. As the market evolves, regulatory approvals and clinical trials will play a pivotal role in determining the success of VEGF-B-targeted therapies. Overall, the Global VEGF-B Market represents a promising frontier in the quest to address unmet medical needs and improve patient outcomes.

Vascular Endothelial Growth Factor B Market

Aflibercept, Aflibercept Biosimilar, CSL-346, Others in the Global Vascular Endothelial Growth Factor B Market:

Aflibercept is a prominent player in the Global Vascular Endothelial Growth Factor B Market, known for its efficacy in inhibiting angiogenesis. It is a recombinant fusion protein that acts as a decoy receptor, binding to VEGF-B and other related growth factors, thereby preventing them from interacting with their natural receptors on the surface of endothelial cells. This mechanism effectively reduces the formation of new blood vessels, which is particularly beneficial in conditions characterized by excessive angiogenesis, such as certain types of cancer and eye diseases like age-related macular degeneration (AMD). Aflibercept has been widely studied and is approved for use in several countries, making it a cornerstone in the treatment of these conditions.

Rectal Cancer, Retinal Vein Occlusion, Diabetic Nephropathy, Others in the Global Vascular Endothelial Growth Factor B Market:

Aflibercept Biosimilar represents a growing segment within the VEGF-B market, offering a more cost-effective alternative to the original biologic. Biosimilars are highly similar to their reference products in terms of safety, efficacy, and quality, but they are typically priced lower, making them more accessible to a broader patient population. The development of aflibercept biosimilars is driven by the expiration of patents on the original product, opening the door for competition and innovation. These biosimilars undergo rigorous testing and regulatory scrutiny to ensure they meet the same standards as the original biologic, providing healthcare providers and patients with confidence in their use.

Global Vascular Endothelial Growth Factor B Market Outlook:

CSL-346 is an investigational therapy targeting VEGF-B, currently under development by CSL Limited. This novel therapeutic approach aims to modulate VEGF-B activity, offering potential benefits in conditions where VEGF-B plays a significant role. While still in the research and development phase, CSL-346 represents the ongoing innovation within the VEGF-B market, as companies seek to expand the therapeutic applications of VEGF-B modulation. The success of CSL-346 and similar investigational therapies will depend on the outcomes of clinical trials and regulatory approvals, which will determine their viability as treatment options.


Report Metric Details
Report Name Vascular Endothelial Growth Factor B Market
Accounted market size in year US$ 603 billion
CAGR 5%
Base Year year
Segment by Type
  • Aflibercept
  • Aflibercept Biosimilar
  • CSL-346
  • Others
Segment by Application
  • Rectal Cancer
  • Retinal Vein Occlusion
  • Diabetic Nephropathy
  • Others
Consumption by Region
  • North America (United States, Canada)
  • Europe (Germany, France, UK, Italy, Russia)
  • Asia-Pacific (China, Japan, South Korea, Taiwan)
  • Southeast Asia (India)
  • Latin America (Mexico, Brazil)
By Company Alteogen Inc, CSL Ltd, Eli Lilly and Company, Formycon AG, Regeneron Pharmaceuticals Inc
Forecast units USD million in value
Report coverage Revenue and volume forecast, company share, competitive landscape, growth factors and trends

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